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β2/β3-di- and α/β3-tetrapeptide derivatives as potent agonists at somatostatin sst4receptors

✍ Scribed by Caroline Nunn; Magnus Rueping; Daniel Langenegger; Edi Schuepbach; Thierry Kimmerlin; Peter Micuch; Konstanze Hurth; Dieter Seebach; Daniel Hoyer


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
280 KB
Volume
367
Category
Article
ISSN
0028-1298

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A novel series of [3.2.1] azabicyclic bi
✍ John A. Lowe III; Shari L. DeNinno; Jotham W. Coe; Lei Zhang; Scot Mente; Raymon 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 243 KB

We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show