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β2-glycoprotein I inhibits vascular endothelial growth factor and basic fibroblast growth factor induced angiogenesis through its amino terminal domain

✍ Scribed by P. YU; F. H. PASSAM; D. M. YU; G. DENYER; S. A. KRILIS

Book ID
109152558
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
443 KB
Volume
6
Category
Article
ISSN
1538-7933

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production