✦ LIBER ✦
β-Turn structure of a tripeptide N-(tert-butoxycarbonyl)-Phe-d-Pro-Gly methyl ester monohydrate
✍ Scribed by Doi, Mitsunobu ;Ichimiya, Yuko ;Asano, Akiko
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 915 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
The title peptide, N-(tert-butoxycarbonyl)phenylalanyl-dprolylglycine methyl ester monohydrate, C 22 H 31 N 3 O 6 ÁH 2 O, was designed to form a -turn structure. The crystal structure exhibits a type-II -turn structure which is stabilized through the intermolecular hydrogen bond between the Gly-NH group and the tert-butyloxycarbonyl O atom. The water molecule further interacts with the carbonyl O atoms of the peptide, stabilizing the -turn structure. The circular dichroism spectra suggest the existence of a stable conformation.