β-Sulfonamido gonadotropin-releasing hormone analogs: synthesis and evaluation of several parent hormone properties

Facile synthesis of N-α-boc-1,2-dialkyl-

Facile synthesis of N-α-boc-1,2-dialkyl-l-histidines: Utility in the synthesis of thyrotropin-releasing hormone (trh) analogs and evaluation of the cns activity

✍ Vikramdeep Monga; Chhuttan Lal Meena; Navneet Kaur; Satyendra Kumar; Chandrashek 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 271 KB

## Abstract magnified image A facile synthesis of __N__‐α‐Boc‐1,2‐dialkyl‐L‐histidines starting from __N__‐α‐trifluoroacetyl‐L‐histidine methyl ester is reported. The key steps involve direct and regiospecific N‐1(τ) ring‐alkylation of the __N__‐α‐trifluoroacetyl‐L‐histidine‐methyl ester by suitab