✦ LIBER ✦
β-Methylthio-aspartic acid: Identification of a novel posttranslational modification in ribosomal protein S12 from escherichia coli
✍ Scribed by Jeffrey A. Kowalak; Kenneth A. Walsh
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 1996
- Tongue
- English
- Weight
- 639 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0961-8368
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✦ Synopsis
Abstract
Utilizing microscale chemical derivatization reactions and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry, we have identified a novel posttranslational modification of aspartic acid, β‐methylthio‐aspartic acid. The modified residue is located at position 88 in ribosomal protein S12 from Escherichia coli, a phylogenetically conserved protein that has been implicated in maintaining translational accuracy of the ribosome.