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β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection

✍ Scribed by Huang, Huatao (author);Fujii, Hideki (author);Sankila, Anna (author);Mahler-Araujo, Betania M. (author);Matsuda, Masanori (author);Cathomas, Gieri (author);Ohgaki, Hiroko (author)

Book ID: 117022753
Publisher: American Society for Investigative Pathology Inc.
Year: 1999
Tongue: English
Weight: 858 KB
Volume: 155
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65496-x

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## Abstract β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of __CTNNB1__, the gene that encodes β‐catenin, have been identified in about one‐fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this study 62 hepatocellular carcinomas (HCCs)