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β-catenin gene alterations in a variety of so-called calcifying odontogenic cysts

✍ Scribed by SANG-GUN AHN; SOO-A KIM; SU-GWAN KIM; SANG-HO LEE; JIN KIM; JUNG-HOON YOON


Book ID
109343794
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
235 KB
Volume
116
Category
Article
ISSN
0365-5555

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Genetic alterations involving exon 3 of
✍ Bas P.L. Wijnhoven; Friedel Nollet; Nico J. De Both; Hugo W. Tilanus; Winand N.M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 268 KB 👁 1 views

␤-catenin has been identified as an oncogene. Phosphorylation of sites encoded by exon 3 of the ␤-catenin gene facilitates degradation of this protein by the adenomatous polyposis coli (apc) gene product. Mutations in these sites or inactivation of apc lead to stabilization of ␤-catenin, which then