β-catenin as a potential key target for tumor suppression

✍ Scribed by Yuejun Fu; Shuhua Zheng; Na An; Takis Athanasopoulos; Linda Popplewell; Aihua Liang; Ke Li; Changchen Hu; Yajing Zhu

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: French
• Weight: 327 KB
• Volume: 129
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.26102

✦ Synopsis

Abstract

β‐catenin is a multifunctional protein identified to be pivotal in embryonic patterning, organogenesis and adult homeostasis. It plays a critical structural role in mediating cadherin junctions and is also an essential transcriptional co‐activator in the canonical Wnt pathway. Evidence has been documented that both the canonical Wnt pathway and cadherin junctions are deregulated or impaired in a plethora of human malignancies. In the light of this, there has been a recent surge in elucidating the mechanisms underlying the etiology of cancer development from the perspective of β‐catenin. Here, we focus on the emerging roles of β‐catenin in the process of tumorigenesis by discussing novel functions of old players and new proteins, mechanisms identified to mediate or interact with β‐catenin and the most recently unraveled clinical implications of β‐catenin regulatory pathways toward tumor suppression.