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β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

✍ Scribed by Kyung-Ran Park; Dongwoo Nam; Hyung-Mun Yun; Seok-Geun Lee; Hyeung-Jin Jang; Gautam Sethi; Somi K. Cho; Kwang Seok Ahn

Book ID: 116335732
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 969 KB
Volume: 312
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2011.08.001

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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest