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β-Carbonylamides in peptide chemistry. I. Optical rotatory properties of N-acetoacetyl amino acids

✍ Scribed by Claudio Toniolo; Fernando Filira; Carlo Di Bello

Publisher: Wiley (John Wiley & Sons)
Year: 1971
Tongue: English
Weight: 323 KB
Volume: 10
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360101119

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✦ Synopsis

The Cotton effects of N-aceBoacety1 amino acids and derivatives were examined by a circular dichroism technique. A correlation has been established between the sign of the Cotton effect and the absolute configuration of the asymmetric center. The L derivatives show, in dioxane, negative circular dichroism curves, whereas the D antipodes present positive curves. The effect of solvent and pH and influence of alkylation a t the amide nitrogen are also discussed.

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β-carbonylamides in peptide chemistry. I

β-carbonylamides in peptide chemistry. II. Ultraviolet absorption and circular dichroic properties of azlactones derived from N-acetoacetyl amino acids

✍ Carlo Di Bello; Fernando Filira; Claudio Toniolo 📂 Article 📅 1971 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 697 KB

Ultraviolel absorphn and circular dichroism spect,ra of azlact,ories derived from N-acetoacetyl amino acids are examined. A number of model compounds of the isomeric forms possibly present in the equilibrium mixtures of these azlactones have also been prepared and their spectral properties compared.