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β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway

✍ Scribed by Grégory Hans; Brigitte Malgrange; François Lallemend; Jessica Crommen; Sabine Wislet-Gendebien; Shibeshih Belachew; Pierre Robe; Bernard Rogister; Gustave Moonen; Jean-Michel Rigo


Book ID
116784204
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
613 KB
Volume
48
Category
Article
ISSN
0028-3908

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Recent studies suggest that hepatocyte growth factor (HGF) functions as a neurotrophic factor in the central nervous system. In this study, we investigated the neuroprotective effect of HGF and its mechanism of action. We used cultured cerebellar granule neurons that underwent apoptosis when the cul