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β-carbolines as benzodiazepine receptor ligands II: Synthesis and benzodiazepine receptor affinity of β-carboline-3-carboxylic acid amides

✍ Scribed by Klaus P. Lippke; Walter E. Müller; Walter G. Schunack

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
564 KB
Volume
74
Category
Article
ISSN
0022-3549

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✦ Synopsis

Numerous 0-carboline-3-carboxamides were synthesized by amidation of p-carboline-3-carboxylic acid, with various amino acids and amino acid esters serving as arnine components, and tested in respect to their affinity for the benzodiazepine receptor in mouse brain membranes. The title compounds have affinities in the low micromolar range. The results are discussed with respect to their relevance for a possible p-carboline structure containing the endogenous ligand of the benzodiazepine receptor.

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