αVβ3 integrin occupancy modulates IGF-I-dependent signaling, proliferation and IGFBP-5 production in human intestinal smooth muscle cells

Expression of the human β3 integrin subu

Expression of the human β3 integrin subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and proliferation

✍ Gang Xi; Laura A. Maile; Sung-Eun Yoo; David R. Clemmons 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB

## Abstract Optimal stimulation of signal transduction and biological functions by IGF‐I in porcine smooth muscle cells (pSMC) requires ligand occupancy of the αVβ3 integrin. Binding of heparin‐binding domain (HBD) of vitronectin (VN) to the cysteine loop (C‐loop) region of β3 is required for pSMC