## Abstract We previously showed that integrin αvβ3 overexpression and engagement by its ligand vitronectin increased adhesion, motility, and proliferation of human ovarian cancer cells. In search of differentially regulated genes involved in these tumor biological events, we previously identified
✦ LIBER ✦
αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells
✍ Scribed by Cruet-Hennequart, Séverine; Maubant, Sylvie; Luis, José; Gauduchon, Pascal; Staedel, Cathy; Dedhar, Shoukat
- Book ID
- 110067462
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 452 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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In addition to their role in cell migration and adhesion, integrins elicit a series of transduction events that regulate cell-cycle progression and apoptosis in a process known as ''outside-in'' signaling. A second mode of integrin regulation known as ''inside-out'' signaling, in which the activatio