α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion
✍ Scribed by Petra Scholze; Anna Ciuraszkiewicz; Florian Groessl; Avi Orr-Urtreger; J. Michael McIntosh; Sigismund Huck
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2011
- Tongue
- English
- Weight
- 462 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1932-8451
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## Abstract Mice with deletions of nicotinic ACh receptor (nAChR) subunit genes are valuable models for studying nAChR functions. We could previously show in the mouse superior cervical ganglion (SCG) that the absence of distinct subunits affects the functional properties of receptors. Here, we hav
BACKGROUND: CP-601927 is a selective a 4 b 2 nicotinic acetylcholine receptor (nAChR) partial agonist. The objective of this study was to assess the potential effects persisting into adulthood when CP-601,927 was administered to neonatal/ juvenile rats. Since the juvenile toxicity study was being pe
Preganglionic nerve trunk of the rat superior cervical ganglion was transected shortly after birth in order to evaluate the influence of preganglionic nerves on the development of acetylcholinesterase and choline acetyltransferase in ganglionic neurons. In spite of an early decentralization, specifi