α2u-Globulins in the urine of male rats: a reliable indicator for α2u-globulin accumulation in the kidney
✍ Scribed by Koichi Saito; Satoshi Uwagawa; Hideo Kaneko; Kunio Shiba; Yoshitaka Tomigahara; Iwao Nakatsuka
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 989 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0300-483X
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The renal accumulation of alpha2u-globulin has been implicated in the tumorigenicity of many nongenotoxic chemicals to the kidney of the male rat. Several chemicals inducing renal tumors in the male rat were shown to bind to alpha2u-globulin. This binding impairs the renal degradation of alpha2u-glo
The Hershberger assay has been proposed as a candidate screening test method for the detection of androgenic and anti-androgenic chemicals and is being validated presently under the test guideline programme of the Organization for Economic Cooperation and Development (OECD). Rat α α α α α 2u -globul