α2-Adrenoceptors in opossum kidney cells couple to stimulation of mitogen-activated protein kinase independently of adenylyl cyclase inhibition

Inhibition of serum-stimulated mitogen a

Inhibition of serum-stimulated mitogen activated protein kinase by 1α,25(OH)2-vitamin D3 in MCF-7 breast cancer cells

✍ Daniela A. Capiati; Ana M. Rossi; Gabriela Picotto; Silvia Benassati; Ricardo L. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB 👁 1 views

## Abstract 1α,25‐Dihydroxyvitamin D~3~ [1α,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1α,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr