α1-Antitrypsin phenotypes in chronic active hepatitis
✍ Scribed by M. L. BASSETT; R. A. BRADBEAR; P. KERLIN; P. CLARK
- Book ID
- 118703614
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 339 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0815-9319
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alpha-1-Antitrypsin deficiency due to homozygous Pi ZZ state is reported to be associated with cirrhosis and hepatocellular carcinoma (HCC); however, the role of heterozygous Pi Z state is not definitely known. In order to investigate the possible association, we studied the phenotypic distribution
The phenotypes of alpha-1-antitrypsin have been analyzed by isoelectric focusing on polyacrylamide gels in 232 healthy Japanese blood donors and in 240 Japanese patients with chronic liver diseases: 69 with chronic active hepatitis, 122 with liver cirrhosis, 41 with hepatocellular carcinoma and 8 wi