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α-Turn Mimetics: Short Peptide α-Helices Composed of Cyclic Metallopentapeptide Modules

✍ Scribed by Kelso, Michael J.; Beyer, Renée L.; Hoang, Huy N.; Lakdawala, Ami S.; Snyder, James P.; Oliver, Warren V.; Robertson, Tom A.; Appleton, Trevor G.; Fairlie, David P.


Book ID
126999389
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
637 KB
Volume
126
Category
Article
ISSN
0002-7863

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A Cyclic Metallopeptide Induces α Helici
✍ Michael J. Kelso; Huy N. Hoang; Warren Oliver; Nikolai Sokolenko; Darren R. Marc 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

About 30 % of all amino acids in proteins are found in a helices. [1] When buried in the hydrophobic interiors of proteins, helices are important in stabilizing tertiary structures, promoting protein folding, and molding active sites of enzymes. However, short peptides (< 15 amino acids) correspondi