α-Thalassemia in Saudi Arabia: deletion pattern

✍ Scribed by M. A. F. El-Hazmi

• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 318 KB
• Volume: 76
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00284921

✦ Synopsis

Alpha-Thalassemia exists at a high prevalence in several regions of Saudi Arabia. The restriction endonucleases BamHI and BglII were used to investigate the molecular basis of deletion type of alpha-thalassemia in 226 subjects from the eastern and 61 subjects from the northwestern regions of the country. The arrangements -alpha/alpha alpha and -alpha/-alpha were common. BglII digestion revealed the existence of rightward deletion in a majority of the cases. Leftward deletions, both homozygous and heterozygous, were also identified. Triple alpha-gene arrangements alpha alpha alpha anti 3.7/ were observed at a low frequency in both regions.