α-synuclein polymorphisms in patients with Gaucher disease and Parkinson disease
✍ Scribed by Altarescu, Gheona; Ioscovich, Daniel; Alcalay, Roy; Zimran, Ari; Elstein, Deborah
- Book ID
- 121892708
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 66 KB
- Volume
- 111
- Category
- Article
- ISSN
- 1096-7192
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## Abstract ## Background: There is an increased incidence of Parkinson's disease among obligate carriers of the common glucocerebrosidase mutations, and among patients with Parkinson disease there is an increased number who are carriers of glucocerebrosidase mutations. A Gaucher mutation is consi
## Abstract Alpha‐synuclein (α‐syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). α‐Syn is also released by neurons and can be detected in biological fluids, such as