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α-Synuclein Monomer Conformations Studied by in Silico and in Vitro FRET

✍ Scribed by Klement, Reinhard; Grubmüller, Helmut; Haas, Elisha


Book ID
122287426
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
39 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract Free‐energy simulations have been used to estimate the change in the conformational stability of short polyalanine α‐helices when one of the alanines is replaced by a proline residue. For substituting proline in the middle of the helix the change in free energy of folding (ΔΔG°) was cal