α-Phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharide

α-Phenyl-n-tert-butyl-nitrone attenuates

α-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced brain injury and improves neurological reflexes and early sensorimotor behavioral performance in juvenile rats

✍ Lir-Wan Fan; Ruei-Feng Chen; Helen J. Mitchell; Rick C. S. Lin; Kimberly L. Simp 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 548 KB

## Abstract Our previous study showed that treatment with α‐phenyl‐__n__‐__tert__‐butyl‐nitrone (PBN) after exposure to lipopolysaccharide (LPS) reduced LPS‐induced white matter injury in the neonatal rat brain. The object of the current study was to further examine whether PBN has long‐lasting pro