α-MSH regulates interleukin-10 expression by human keratinocytes
✍ Scribed by P. Redondo; Jesús García-Foncillas; Iouri Okroujnov; Eva Bandrés
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 105 KB
- Volume
- 290
- Category
- Article
- ISSN
- 0340-3696
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a-MSH, a proopiomelanocortin (POMC)-derived peptide, is known to be produced in the pituitary, the skin, and melanoma tumors and to possess many biological effects, mainly on melanocyte pigmentation and growth. Moreover, the melanocyte expresses adhesion molecules, including ICAM-1. The latter has b
## Abstract Recent data indicate a major role for IL‐10 in suppressing immune and inflammatory reactions. To date, expression of human IL‐10 has been attributed primarily to helper T lymphocytes, activated monocytes, and neoplastic B cells, and was often found to be associated with IL‐6 expression.