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α-metalation of 1-(tert-butoxycarbonyl)-1,4-dihydropyridines

✍ Scribed by Daniel L. Comins


Book ID
104221381
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
172 KB
Volume
24
Category
Article
ISSN
0040-4039

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α-Metalation of 1-(tert-butoxycarbonyl)-
✍ Daniel L. Comins; Michael A. Weglarz; Sean O'Connor 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 195 KB

## The a-metalation-alkylation of I-(E-butoxycarbonyl)-I,2-dihydropyridines is described and utilized in the synthesis of (+?&-n&m?.

Metalation of 1,4-dihydropyridine esters
✍ Graham S. Poindexter; Michael A. Foley; Joseph F. Licause 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 209 KB

Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic esters are metalated at the NH and the C-2 methyl positions via treatment with two equivalents of n-butyl lithium. The resulting dilithio species can be treated with a variety of electrophiles to furnish C-2 methyl functionalized dihydropyridine