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α-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet β-cells

✍ Scribed by Amelia M. Silva; June Liu-Gentry; Adam S. Dickey; David W. Barnett; Stanley Misler

Book ID
110113275
Publisher
Cambridge University Press
Year
2005
Tongue
English
Weight
427 KB
Volume
565
Category
Article
ISSN
0022-3751

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Coupling of exocytosis to depolarization
Coupling of exocytosis to depolarization in rat pancreatic islet β-cells: effects of Ca2+, Sr2+and Ba2+-containing extracellular solutions
✍ David W. Barnett; Stanley Misler 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 333 KB

Using rat [3-cells we present evidence that Sr 2+ and Ba 2+, like Ca 2+, support depolarization-induced increases in membrane capacitance which reflect insulin granule exocytosis. Even with identical total charge entry, Sr 2+ and Ba 2+ are 3-5 and 20-fold less effective than Ca 2+ in supporting rele