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α-Lactalbumin Forms with Oleic Acid a High Molecular Weight Complex Displaying Cytotoxic Activity

✍ Scribed by Spolaore, Barbara; Pinato, Odra; Canton, Marcella; Zambonin, Marcello; Polverino de Laureto, Patrizia; Fontana, Angelo

Book ID: 111685062
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 921 KB
Volume: 49
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi1012832

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The presence of a high-molecular weight complex with acid phosphatase activity in the cytosol of human mammary tumors is reported. This complex appeared in the cytosol after tissue homogenization in the presence of dithiotreitol, with or without Triton X-100 and at acidic or neutral pH. Upon gel ele