(—)-α-isosparteine from Lupinus argenteus var. stenophyllus

✍ Scribed by William J. Keller; Brian N. Meyer; Jerry L. McLaughlin

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 287 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720523

✦ Synopsis

0 Combined GLC-mass spectrometry revealed that an unidentified sparteine isomer was the major component of an alkaloid extract of the aboveground portions of Lupinus argenteus Pursh. var. stenophyllus (Rydb.) Davis (Leguminosae). After isolation, this alkaloid was characterized as the least common of the known sparteine isomers, (-)-a-isosparteine. A preliminary pharmacological study showed (-)a-isosparteine to have a more rapid onset and a shorter duration of action when compared with (-)-sparteine on rat myocardium. Keyphrases Lupinus argenteus var. stenophyllus-( -)-a-isosparteine, GLC-mass spectrometry, sparteine isomer 0 (-)-a-Isosparteine-Lupinus argenteus var. sterzophyllus, GLC-mass spectrometry, sparteine isomer GLC-mass spectrometry-(-)-a-isosparteine from Lupinus argenteus var. stenophyllus, sparteine isomer 'H-NMR spectra were recorded on a Perkin-Elmer model R-24 spectrometer.

W-NMFt spectra were obtained on a Varian XL-200 spectrometer. GLC was conducted using a Hewlett-Packard model 5720A gas chromatograph. Combined GLC-mass spectrometry was carried out with a Du Pont 321 Dimaspec low-resolution mass spectrometer interfaced with a 320 data reduction system. Melting points were determined on a Fisher-Johns melting point apparatus and are uncorrected. Optical rotations were measured with a Perkin-Elmer model 241 polarimeter.