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α-Bromination of acid halides

✍ Scribed by John G. Gleason; David N. Harpp


Book ID
104249238
Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
167 KB
Volume
11
Category
Article
ISSN
0040-4039

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Reaction of (S)-2-chloro-3-phenylpropanoic acid derivatives with NBS gave the corresponding 3-bromo-2chloro derivatives with a preference for the formation of the (2R,3S) isomers over the (2R,3R) isomers. The stereoselectivity was affected by the nature of the carboxylic acid derivative. Reaction of