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α-aminoazoles in the Synthesis of heterocycles: V. Synthesis of azolo[1,5-a]pyrimidines from 2-ethoxyvinyl trifluoromethyl ketones and 2,2-diethoxyvinyl trifluoromethyl ketone

✍ Scribed by E. E. Emelina; A. A. Petrov


Book ID
111464965
Publisher
SP MAIK Nauka/Interperiodica
Year
2009
Tongue
English
Weight
196 KB
Volume
45
Category
Article
ISSN
1070-4280

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1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCI catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbinols are obtained with symmetric and unsymmetri