✦ LIBER ✦
α-Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin
✍ Scribed by Amal Shibli; Reem Smoum; Israel Goldberg; Abraham Rubinstein; Morris Srebnik
- Book ID
- 101569367
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 120 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0268-2605
- DOI
- 10.1002/aoc.1095
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✦ Synopsis
Abstract
The first examples of α‐amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom. Copyright © 2006 John Wiley & Sons, Ltd.