𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Über Pterinchemie 52. Mittelung [1] Eine eindeutige Synthese isomerenfreier Pteroyl-γ-L-glutamyl-γ-L-glutamyl-L-glutaminsäure

✍ Scribed by Pradip K. Sengupta; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1975
Tongue
German
Weight
802 KB
Volume
58
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new and unequivocal synthesis of pteroyl‐γ‐L‐glutamyl‐γ‐L‐glutamyl‐L‐glutamic acid free of isomers is described. A melt of N(2′)‐acetyl‐6‐formylpterine and tetramethyl‐N‐(p‐amino‐benzoyl)‐γ‐L‐glutamyl‐γ‐L‐glutamyl‐L‐glutamatewas quantitatively converted to the corresponding azomethin IX. NaBH~4~‐reduction followed by basic hydrolysis of acetyl and methylester groups gives pure pteroyl‐γ‐L‐glutamyl‐γ‐L‐glutamyl‐L‐glutamic acid in good yield.

📜 SIMILAR VOLUMES

Über Pterinchemie. 45. Mitteilung. Eine
Über Pterinchemie. 45. Mitteilung. Eine neue und eindeutige Synthese isomerenfreier Pteroyl-λ-L-glutamyl-L-glutaminsäure
✍ Esam Khalifa; Jost H. Bieri; Max Viscontini 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 German ⚖ 623 KB

## Abstract A new and unequivocal synthesis of pteroyl‐λ‐L‐glutamyl‐L‐glutamic acid free of isomers is described. A melt of N(2′)‐acetyl‐6‐formylpterine and trimethyl‐N‐(__p__‐amino‐benzoyl)‐λ‐L‐glutamyl‐L‐glutamate was quantitatively converted to 6‐azomethin‐pterine‐trimethylester XI. NaBH~4~‐redu