✦ LIBER ✦
Über die Konstitutionsermittlung und Synthese eines Metaboliten von N-(γ-Dimethylaminopropyl)-iminodibenzyl-hydrochlorid (Tofranil®)
✍ Scribed by W. Schindler
- Publisher
- John Wiley and Sons
- Year
- 1960
- Tongue
- German
- Weight
- 471 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Oxidation of N‐(γ‐dimethylaminopropyl)‐iminodibenzyl hydrochloride (Tofranil®) with molecular oxygen in the presence of Fe^2+^ salts, ethylenediamine‐tetraacetic acid and ascorbic acid leads to N‐(γ‐dimethylaminopropyl)‐2‐hydroxy‐iminodibenzyl in moderate yield. This product is identical with a metabolite of Tofranil® isolated from human urine.