Über die Bedeutung des Histidins im «Thyrotropin-releasing» Hormon (TRH)

✍ Scribed by D. Gillessen; R. O. Studer; F. Piva; H. Steiner

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: German
• Weight: 549 KB
• Volume: 54
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19710540513

✦ Synopsis

Abstract

The syntheses and biological activities of 4 analogues of the thyrotropin‐releasing hormone (TRH) are described. In these analogues the histidine residue has been replaced by L‐lysine, L‐α,γ‐diaminobutyric acid, β‐(3‐pyrazolyl)‐L‐alanine, and L‐arginine. All analogues exhibited the characteristic biological responses of TRH. For the β‐(3‐pyrazolyl)‐L‐alanine analogue as well as for TRH the bioassays suggest an induction of a strong and rapid resynthesis of thyrotropin (TSH) in higher (μg) concentrations.