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Über das Verhalten von α-Phenyl-α-äthyl-glutarimid im Tierkörper. IIIsolierung und Strukturaufklärung der Metaboliten vonα-Phenyl-α-äthyl-glutarimid

✍ Scribed by J. Kebrle; K. Schmid; K. Hoffmann; J. P. Vuilleumier; K. Bernhard

Publisher: John Wiley and Sons
Year: 1959
Tongue: German
Weight: 541 KB
Volume: 42
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19590420204

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✦ Synopsis

Abstract

The detoxification of a‐phenyl‐a‐ethyl‐glutarimide («Doriden») in the animal organism occurs principally by coupling with glucuronic acid. The products of the glucuronic acid coupling were isolated from the urine and were found to be pharmacologically inactive. The main components of the glucuronic mixture were isolated as crystalline derivatives; their structure was established by degradation and synthesis of the aglucone residue.

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✍ Karl Bernhard; M. Just; J. P. Vuilleumier; G. Brubacher 📂 Article 📅 1956 🏛 John Wiley and Sons 🌐 German ⚖ 578 KB

## Abstract The metabolism of α‐phenyl‐α‐ethylglutarimide (“Doriden”), a soporific, labelled with ^14^C either in the ring or in the side‐chain, has been studied in the rat.