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Über aktivierte Ester VI. Tetrahydro-pyranyl-Derivate von Aminosäuren und ihre Umsetzungen

✍ Scribed by B. Iselin; R. Schwyzer

Publisher: John Wiley and Sons
Year: 1956
Tongue: German
Weight: 552 KB
Volume: 39
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19560390108

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✦ Synopsis

Abstract

Whereas the usefulness of the tetrahydro‐pyranyl residue for the activation of esters is rather limited, it is of definite value for the temporary etherification of the hydroxyl groups of tyrosine and serine derivatives. The stability of tetrahydro‐pyranyl ethers towards alkali and the rapid hydrolysis by acids permit a great variety of transformations of these amino acid derivatives. The only disadvantage adherent to the use of the tetrahydro‐pyranyl group is the introduction of a new asymmetric center.

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✍ R. Schwyzer; M. Feurer; B. Iselin 📂 Article 📅 1955 🏛 John Wiley and Sons 🌐 German ⚖ 577 KB

## Abstract A number of activated esters of amino acid and peptide derivatives were reacted with various organic amines, including amino acid esters. The good yields obtained, and the mild reaction conditions make it seem possible that the activated ester method of acylation may be of good use in p