✦ LIBER ✦
Über aktivierte Ester V. Verwendung der Cyanmethylester-Methode zur Herstellung von (N-Carbobenzoxy-S-benzyl-L-cysteinyl)-L-tyrosyl-L-isoleucin auf verschiedenen Wegen
✍ Scribed by B. Iselin; M. Feurer; R. Schwyzer
- Publisher
- John Wiley and Sons
- Year
- 1955
- Tongue
- German
- Weight
- 630 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
A study on the synthesis of (N‐carbobenzoxy‐S‐benzyl‐L‐cysteinyl)‐L‐tyrosyl‐L‐isoleucine (XII) by the activated ester method has shown that the cyanomethyl esters prove useful for preparing relatively complicated peptides, especially if acetic acid is used as a catalyst. An important feature of the method is the fact that the cyanomethyl ester of (N‐carbobenzoxy‐S‐benzyl‐L‐cysteinyl)‐L‐tyrosine on hydrolysis or aminolysis produces derivatives of L‐cysteinyl‐L‐tyrosine without any signs of racemisation.