✦ LIBER ✦
Étude chez le singe rhésus des modifications du sommeil induites par le S. 1694 en administration prolongée
✍ Scribed by E. Balzamo; G. Vuillon-Cacciuttolo
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 569 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
Five adult Macaca mulatta were studied during chronic administration (24 days) of S. 1694 (10 mg/kg, i.m.). This substance induced a significant increase of the first awakening (delaying sleep onset) and an enhancement of the duration of REM and stage 4 sleep. After withdrawal, the waking effect desappeared, but the increase in stage 4 sleep was maintained for one week and REM enhancement kept rising for 15 days. This observation of long-term action underlined the validity of drug experiments in chronic treatment: S. 1694 might set a new type of monoaminergic systems regulation.