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“In vitro” model for the evaluation of drug distribution and plasma protein-binding relationships

✍ Scribed by DALPOZZO, A; DONZELLI, G; RODRIQUEZ, L; TAJANA, A

Book ID
120352470
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
428 KB
Volume
50
Category
Article
ISSN
0378-5173

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Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an