Zur Synthese und Abwandlung N-substituierter 2(1 H)-Pyrimidin-thione - Ein einfacher Zugang zu Pyrimidino[2,3-b]1,3,4-thiadiazoliumsalzen

✍ Scribed by Doz. Dr. Jürgen Liebscher; Doz. Dr. Horst Hartmann

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 259 KB
• Volume: 324
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/prac.19823240612

✦ Synopsis

Synthesis and Transformation of N‐substituted 2(1 H)‐Pyrimidine‐thiones – A Simple Route to Pyrimidino [2,3‐b]1,3,4‐thiadiazolium Salts

N‐substituted 2(1 H)‐pyrimidine‐thiones 4–6 can be prepared by reaction of primary amines or unsubstituted or substituted hydrazines with 3‐isothiocyanato‐propene‐(2)‐iminium salts 2, which are easily aviable from 3‐chloro‐propene‐(2)‐iminium salts 1. The 2(1 H)‐pyrimidine‐thiones are transformed into 2‐alkylmercapto‐pyrimidinium salts 7 and pyrimidino[2,3‐b]1,3,4‐thiadiazolium salts 9, respectively.