Zur Struktur von Papulacandin B, einem neuen antifungischen Antibiotikum. Vorläufige Mitteilung

✍ Scribed by Peter Traxler; Hans Fritz; Wilhelm J. Richter

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: German
• Weight: 304 KB
• Volume: 60
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19770600230

✦ Synopsis

On the structure of Papulacandin B, a new antibiotic with antifungal activity

Structure 1 has been established for Papulacandin B (C~47~H~64~O~17~), a new antibiotic from Papularia sphaerosperma (PERS.) HÖhnel by means of spectral analysis of 1 and some derivatives and degradation products. Base catalysed hydrolysis of 1 gave the two unsaturated fatty acids 2 and 3 and the spirocyclic diglycosid 4. The structure of 4 was determined by further degradation reactions.