Zur Methodik und Anwendung einer zeitdefinierten Harnsammlung im S�uglingsalter

✍ Scribed by Gehler, J. ;Pilarzyk, I. ;Thede, H. ;Willers, D. ;K�bler, W.

• Publisher: Springer-Verlag
• Year: 1973
• Weight: 610 KB
• Volume: 115
• Category: Article
• ISSN: 0044-2917
• DOI: 10.1007/bf00438741

✦ Synopsis

1. A system is described which permits urine collection from infants in separated portions with an exact time registration.

2. 24-hour ereatinine excretions are observed in the separated spontaneous urine portions of 32 mature and 18 premature infants. Noticeably its current is strictly linear to time. These studies also demonstrate that in infants incomplete voiding of the bladder very rarely occurs (less than 2% of the observed mietions).

The creatinine coefficient (rag ereatinine/kg body weight in 24 hrs), however, shows such a large variation (17.3 ~_ 4.7%) that it can be useful only to detect very aggravating collecting errors.

3. The excretion of sodium, potassium, chloride, water, calcium, and phosphate with the urine manifests decisively larger deviations from the linear substance/time proportion. Errors of less than 20%, compared with tile 24-hour excretion, therefore can be attained not earlier than after 12.8--18.8 hrs collecting time.

4. Principles and practical application of the time-defined urine collection are demonstrated for the use in pharmacokinetie studies and it is made evident that it can be an important supplement to the plasma concentration curves. In special eases it can save considerable numbers of blood sampling.