✦ LIBER ✦

Zur Herstellung von Oxindol-Derivaten aus o-Chlor-nitrobenzolen und Cyanessigsäure- bzw. Malonsäure-estern

✍ Scribed by C. A. Grob; O. Weissbach

Publisher: John Wiley and Sons
Year: 1961
Tongue: German
Weight: 420 KB
Volume: 44
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19610440630

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✦ Synopsis

Chlorobenzenes activated by a single nitro group in the ortho position undergo smooth nucleophilic substitution by the potassium salts of ethyl cyanoacetate and ethyl malonate in tert.‐butanol as solvent. The 2‐nitrophenyl malonic ester derivates (2a) and (2b) so obtained are easily converted into 2‐nitrophenyl acetic acid and derivatives of oxindole and indole respectively.

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