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Zuclopenthixol dihydrochloride in the management of behavioural disorders in elderly demented patients: A dose-ranging study

✍ Scribed by Tamirisa Venkateswarlu; Christopher John Staley; Charles David Neal

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
426 KB
Volume
5
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Restlessness, aggressiveness and agitation in elderly people with dementia sometimes requires treatment with drugs. Often patients cannot be calmed by soothing measures alone, and neuroleptics in low dosages are frequently used. This open dose ranging study was proposed to determine the optimum dosage of oral zuclopenthixol for patients with dementia and behavioural problems. Twenty hospital inpatients entered the study of whom 14 were established on a therapeutic dosage (the lowest dose providing maximum clinical benefit without the emergence of unwanted symptoms) and maintained for four weeks. Eleven of the 14 patients who were established on a therapeutic dosage received either 2 or 4mg bd. Patients' symptoms were shown to have significantly improved during the study.

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Zuclopenthixol and thioridazine in the treatment of aggressive, elderly patients: A double-blind, controlled, multicentre study
✍ A. Harenko; I. Alanen; S. Elovaara; S. GinstrΓΆm; U. Hagert; M. SavijΓ€rvi; A. Yli πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 441 KB πŸ‘ 1 views

A four-week double-blind study of zuclopenthixol and thioridazine in 64 elderly patients presenting with hostility or restlessness has been carried out in five Finnish mental hospitals. The ages of the patients in the two groups ranged from 64 to 97 years. The initial daily dose was 2-6 mg zuclopent