ZrCl4/[bmim]BF4-catalyzed condensation of salicylaldehydes and malononitrile: Single-step synthesis of 3-cyanocoumarin derivatives

✍ Scribed by Hassan Valizadeh; Manzar Mahmoodian; Hamid Gholipour

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 76 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.593

✦ Synopsis

Abstract

A versatile and efficient single‐step route to 3‐cyanocoumarins via Knoevenagel condensation of salicylaldehydes and malononitrile using ZrCl~4~ as the catalyst (15 mol %) in ionic liquid 1‐(n‐butyl)‐3‐methylimidazolium tetrafluoroborate as reaction medium and catalyst is described. The novel procedure features single step, short reaction time, good yields, and simple workup. J. Heterocyclic Chem., (2011).