Radical mediated stereoselective synthes
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G.V.M Sharma; A.Subash Chander; V Goverdhan Reddy; K Krishnudu; M.H.V Ramana Rao
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Article
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2000
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Elsevier Science
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French
β 118 KB
Stereoselective synthesis of chiral spiroacetals starting from enol-ester 1, derived from D-manno lactone, is described. The strategy involves 1,4-addition of a variety of alcohols to 1 in the presence of NBS to give Ξ±bromo acetals, which undergo a regio-and stereoselective radical cyclisation to gi