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ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation

✍ Scribed by Reddy, Usha R; Basu, Amitabha; Bannerman, Peter; Ikegaki, Naohiko; Reddy, C Damodara; Pleasure, David


Book ID
110062228
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
630 KB
Volume
18
Category
Article
ISSN
0950-9232

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Retinoic acid-induced AP-1 transcription
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## Abstract Retinoic acid (RA) inhibits growth and induces differentiation of B16 mouse melanoma cells. These effects are accompanied by a large increase in PKCΞ± mRNA and protein levels and surprisingly an increase in activating protein‐1 (AP‐1) transcriptional activity. To further investigate the