Recent advances in xenotransplantation
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Mauro S Sandrin; Ian FC McKenzie
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Article
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1999
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Elsevier Science
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English
β 48 KB
The major barrier to clinically successful pig-to-human xenotransplantation is antibody-and complement-dependent hyperacute rejection, known to be due to host anti-GalΞ±(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expre