Zirconium(IV) oxide chloride and anhydrous copper(II) sulfate mediated synthesis of 2-substituted benzothiazoles

✍ Scribed by Firouz Matloubi Moghaddam; Hossein Ismaili; Ghasem Rezanejade Bardajee

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 409 KB
• Volume: 17
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20191

✦ Synopsis

A simple, fast and efficient benign procedure has been developed for one-pot synthesis of 2-substituted benzothiazoles in the presence of zirconium(IV) oxide chloride octahydrate (ZrOCl 2 •8H 2 O) and anhydrous copper(II) sulfate. The reaction of 2-aminothiophenol with aldehydes and anhydrides was carried out efficiently in solventfree conditions with or without microwave irradiation, and adducts were produced in good to excellent yields.