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Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes: ZACA–Lipase-Catalyzed Acetylation Synergy

✍ Scribed by Zhihong Huang; Ze Tan; Tibor Novak; Gangguo Zhu; Ei-ichi Negishi


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
177 KB
Volume
349
Category
Article
ISSN
1615-4150

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✦ Synopsis


Abstract

ZACA–lipase‐catalyzed acetylation tandem reactions provide highly efficient and selective routes to either (R)‐ or (S)‐2‐methyl‐1‐alkanols, making, for the first time, the ZACA‐based asymmetric synthesis of 2‐methyl‐1‐alkanols widely applicable and satisfactory.


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